[conspire] COVID-19: the bradykinin storm hypothesis

[Deirdre Saoirse Moen]

https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63 <https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-31cb8eba9d63>

This is the most lay-accessible version of it I’ve read, and the bit about hyaluronic acid is particularly illuminating about why people die so readily when things go south. Because yeah, hyaluronic acid’s something you add to face creams to keep moisture sticking on your face, but it’s absolutely not something you want in your lungs in quantity. :O

FWIW, some of the so-called bizarre symptoms of covid aren’t actually that bizarre if you know about:

1. Filopodia: https://www.ucsf.edu/news/2020/06/417936/covid-19-relies-cells-master-regulators-survival <https://www.ucsf.edu/news/2020/06/417936/covid-19-relies-cells-master-regulators-survival> - normally used to help create webs for clotting (and part of intracellular structure), but hijacked by viruses like HIV, ebola, dengue, and, yes, SARS-CoV-2 to present virions in a “want some candy, little girl?” maneuver. Anyhow, the side effects it induces underlies some weird symptoms, partly because the cells have to have massive changes in upregulation and downregulation of intracellular processes.

2. Dysautonomia (previously covered). That covers a ton of ground, and most of the weird symptoms, frankly (including most of the thyroid ones).

Deirdre
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