From: BLANTON@VAX2.DSEG.TI.COM Subject: Healthy skepticism Message-ID: <9212191338.AA29663@lll-winken.llnl.gov> Date: Sat, 19 Dec 1992 07:28:34 -0600 The following article by Tim Gorski appeared in the latest issue of "The Skeptic", the newsletter of the North Texas Skeptics. As always, free distribution for non-commercial purposes is allowed (and encouraged). ---------------- Healthy Skepticism Medical "Pathies" By Tim Gorski, M.D. First in a Series Anyone looking into the mushrooming "alternative medicine" literature is apt to encounter a number of "-pathies" that generally obscure, rather than explain. Homeopathy, thanks to the tireless efforts of its promoters, is one of these that has been gaining new popularity in recent years. In the Christmas 1992 The Sharper Image catalog, for example, right there on page 56, are "Longevity" products. The ad copy goes so far as to say that it's "medical science" and "clinically proven," both of which claims are simply and utterly false. Many women have also bought the worthless homeopathic remedy intended to cure vaginal yeast infections, "Yeastgard." And there's a whole line of homeopathic quack products sold under the names "Bioforce," "Hyland's," and "NuAge." Just as effective, though, and lots cheaper, are the doctor kits sold in toy departments that include jelly beans of different colors labeled "heart pills," "kidney pills," and so on. Invented by Samuel Hahnemann (1755-1843) in the prescientific era of medicine, homeopathy is a self-contained system of theory and practice, which is to say, a pseudoscience. It's based on several fantastic notions which modern quacks, nevertheless, manage to sell to their victims. The first of these ideas is that diseases should be recognized primarily as combinations of symptoms caused by psora, which is to say, an itch. Hahnemann went so far as to argue that in olden times maladies including epilepsy, asthma, and cancer were actually simple skin disorders which, because of their suppression by habits of hygiene, have been driven inside the body, so to speak. The second is the principle that like cures like, for which homeopathy is named. And the third is that substances which can cause given symptoms can be used to treat those same symptoms by administering them as extreme dilutions. Ipecac, for instance, is an emetic used to induce vomiting in cases of poisoning. A small dose of ipecac, according to the doctrine of homeopathy, can therefore be used to cure nausea and vomiting. Not just a small dose of ipecac can be used, though, and not even a very, very, very small dose. Rather, according to Hahnemann and the homeopaths, the effective dose is a dilution so extreme that not even one molecule of the substance is likely to be still present! And Hahnemann taught that the more diluted a preparation was, the more effective it was, and that a single dose of a homeopathic remedy could exert therapeutic effects a month or more after being given! No Scientific Basis Now in a prescientific era during which effective medical measures were few, using smaller doses instead of larger and waiting patiently to see what would happen probably did give better results. But today the grave logical and scientific problems of homeopathy are obvious. The chief difficulty, of course, is how a substance could exert any effect when it isn't even present in what's given to the patient. The presumably inactive material in which the active agent is diluted (the diluent) would itself become the "medicine." But it would have to somehow transmit the effects of the active agent ... Homeopaths claim that this happens by the diluent being imbued through the process of dilution, which involves a ritual of vigorous shaking which they call "succussion," with "energies" or "vibrations" of the active substance. Never mind that these "energies" and "vibrations" can't be measured and are otherwise scientifically unknown and unnecessary. And never mind that the diluents used can't be shown to be absolutely 100% free of all contaminants whatsoever, even including dissolved atmospheric gases. And especially never mind that whatever diluent is used is unquestionably swarming with the "energies" and "vibrations" of everything that its molecules ever came into contact with. More importantly, no body of reliable evidence supports the doctrines of homeopathy. One study showed a very small, but statistically significant, effect of homeopathic remedies used to treat arthritis pain. But of course at a statistical significance of P <= .05 (meaning that the results could have arisen by chance with a probability of 1 in 20), one in twenty clinical trials, on average, can be expected to show a variance with the null hypothesis. One study does not a science make. And, in fact, other clinical trials of homeopathic remedies have shown no benefits compared to placebo. The "Remembering Water" Caper In 1988 a French homeopath, Jacques Benveniste, and collaborators at his lab claimed to show that extreme dilutions of an antibody could still cause effects on target cells. A paper appeared in the British journal Nature which was pounced on by homeopathy promoters as the long awaited "proof" that "It works!" and the study is still so cited. But, miraculously, investigators from Nature and the National Institutes of Health joined by James Randi and others caused replications of the experiment to show the expected negative results. Another investigator using a similar system published negative results soon after and the whole affair died down except in the minds of homeopathy apologists. But an important feature of these events went completely unnoticed. And that is that the effect of an extreme - homeopathic - dilution of an antibody should have been the opposite of the usual antibody effect on target cells. So, even if the Benveniste claims had panned out, they could not have provided the objective support that homeopathy remains so utterly without. (See the Winter 1989 issue of The Skeptical Inquirer for a report on the Benveniste "remembering water" affair - Ed.) Unfortunately, homeopathic quackery has enjoyed something of an advantage over other forms of health fraud in that the 1938 legislation which created the U.S. Food and Drug Administration recognized the Homeopathic Pharmacopoeia. Homeopathic "drugs" are not thereby exempted from having to be shown to be safe and effective but the FDA indicated that it wouldn't challenge homeopathic remedies being sold to practitioners to treat "minor" ailments. Presumably someone at the FDA thought that homeopaths would satisfy themselves with using their placebos to treat hypochondriasis. Instead, the promotion of homeopathic remedies has exploded and the FDA has failed to enforce the law. If homeopathic remedies are nothing but worthless placebos, of course, they might be assumed to be as safe as their diluents, which are often water or grain alcohol. But if, as homeopaths insist, their treatments actually have pharmacologic effects, they should be held to the same standards of safety and efficacy as other drugs. This same stumbling block has been encountered in the European efforts to unite their separate economies since homeopathy is very popular, for example, in France. Simply put, homeopathy is medical quackery. Now you know why. Next month: Naturopathy, Osteopathy, and Allopathy. Update: Pro-Quackery Bill Now Law The marginal political/legal advantage of homeopathic products is passing. Utah Senator Orrin Hatch's Health Freedom Act of 1992 discussed here last month passed both houses of Congress as a rider to an appropriations bill and was signed into law by President Bush. Drafted with the help of a health food industry group, the legislation puts an effective end to the FDA's efforts to protect consumers in the burgeoning marketplace of vitamins, supplements and health foods. Henceforth, as long as quacks continue to follow their established practices of claiming to have "scientific evidence" to support the wondrous benefits of their "natural and nutritional" products, regulatory authorities will be powerless to stop their deceptive schemes. Those engaged in these scams have indeed gained new freedom. Consumers, on the other hand, are as yet unaware that open season has been declared on them by the nutritional profiteers. Caveat emptor! This information is provided by the D/FW Council Against Health Fraud. For more information, or to report suspected health fraud, please contact the Council at Box 202577, Arlington, TX, 76006, or call metro 214-263-8989. Dr. Gorski is a practicing physician, chairman of the D/FW Council Against Health Fraud and an NTS Technical Advisor. +-----------------------------------------------------------------+ | John Blanton | | Secretary, North Texas Skeptics | | blanton@lobby.ti.com | +-----------------------------------------------------------------+