<div dir="auto"><div dir="auto">J&J encodes the same full spike D614G variant with 2 proline substitutions to encode the pre-fusion spike protein as the mRNA vaccines.</div><div dir="auto"><br></div><div dir="auto">Reference:</div><div>How the Johnson & Johnson Vaccine Works <a href="https://nyti.ms/2WuvMsA">https://nyti.ms/2WuvMsA</a><br><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Sat, Jan 1, 2022, 10:13 PM Rick Moen <<a href="mailto:rick@linuxmafia.com">rick@linuxmafia.com</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Quoting Paul Zander (<a href="mailto:paulz@ieee.org" target="_blank" rel="noreferrer">paulz@ieee.org</a>):<br>
<br>
[snip that you had Pfizer and the Pfizer booster]<br>
<br>
> Now I am wondering if my next booster, whenever that is promoted,<br>
> should be J&J so as to add a different line of defense to the castle<br>
> model. <br>
<br>
Awfully good question. I'll do you a favour and not give you a poorly<br>
informed guess based on quickly winging it. ;-><br>
<br>
We're all amateur virologists/epidemilogists, at this point, trying to<br>
sort out a lot of ambivalent information and hoping to filter out the<br>
rubbish, and (I'm sure like you) I try to be super-careful, but one way<br>
to increase the chance of screwing up would be to overconfidently just<br>
Web-search a question and post what you find as the answer, without <br>
a good grounding in the subject. And I'm going to be properly humble<br>
and say I just don't know enough.<br>
<br>
That having been said, if you want to see what the Wisdom of the Web has<br>
to say, Web-search "vaccine mixing". You'll find a lot of stuff from<br>
reporters quoting seemingly credible medical authorities. However, what<br>
you mostly find is medical authorities endorsing following up an initial<br>
J&J regime with one of the two mRNA boosters, on grounds of the latter<br>
not coding for the for the exact same part of the spike protein.<br>
<br>
Whether informed sources would recommend J&J as a 2nd booster after<br>
three Pfizer shots is unclear. Complicating that calculation is the<br>
observed fact that the J&J vaccine has never generated as strong an<br>
immune response as the mRNA vaccines.<br>
<br>
If you trust your primary care physician's advice, asking him/her might<br>
be a reasonable thing to do.<br>
<br>
-- <br>
Cheers, "Public health is not private health. Epidemics are not personal<br>
Rick Moen diseases, and pandemics are not even national: They take place <br>
<a href="mailto:rick@linuxmafia.com" target="_blank" rel="noreferrer">rick@linuxmafia.com</a> across the shared immune system of human society."<br>
McQ! (4x80) -- Indi Samarajiva, <a href="https://t.co/bW2w059PYp" rel="noreferrer noreferrer" target="_blank">https://t.co/bW2w059PYp</a><br>
<br>
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</blockquote></div></div></div>