<div dir="auto">The J&J has an ultra rare side-effect. It can cause thrombocytopenia syndrome, which can impair clotting and cause internal bleeding. The highest risk is for childbearing age women. It is related to an Adenovirus vector protein attaching to Platelet factor 4 (pf4).<div dir="auto">Pf4 is a cytokine involved in blood clotting. </div><div dir="auto">A similar syndrome is caused by heparin.</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Sat, Jan 1, 2022, 11:04 PM Les Faby <<a href="mailto:lfaby2018@gmail.com" target="_blank" rel="noreferrer">lfaby2018@gmail.com</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex"><div dir="auto"><div dir="auto">J&J encodes the same full spike D614G variant with 2 proline substitutions to encode the pre-fusion spike protein as the mRNA vaccines.</div><div dir="auto"><br></div><div dir="auto">Reference:</div><div>How the Johnson & Johnson Vaccine Works <a href="https://nyti.ms/2WuvMsA" rel="noreferrer noreferrer" target="_blank">https://nyti.ms/2WuvMsA</a><br><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Sat, Jan 1, 2022, 10:13 PM Rick Moen <<a href="mailto:rick@linuxmafia.com" rel="noreferrer noreferrer" target="_blank">rick@linuxmafia.com</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0 0 0 .8ex;border-left:1px #ccc solid;padding-left:1ex">Quoting Paul Zander (<a href="mailto:paulz@ieee.org" rel="noreferrer noreferrer noreferrer" target="_blank">paulz@ieee.org</a>):<br>
<br>
[snip that you had Pfizer and the Pfizer booster]<br>
<br>
> Now I am wondering if my next booster, whenever that is promoted,<br>
> should be J&J so as to add a different line of defense to the castle<br>
> model. <br>
<br>
Awfully good question. I'll do you a favour and not give you a poorly<br>
informed guess based on quickly winging it. ;-><br>
<br>
We're all amateur virologists/epidemilogists, at this point, trying to<br>
sort out a lot of ambivalent information and hoping to filter out the<br>
rubbish, and (I'm sure like you) I try to be super-careful, but one way<br>
to increase the chance of screwing up would be to overconfidently just<br>
Web-search a question and post what you find as the answer, without <br>
a good grounding in the subject. And I'm going to be properly humble<br>
and say I just don't know enough.<br>
<br>
That having been said, if you want to see what the Wisdom of the Web has<br>
to say, Web-search "vaccine mixing". You'll find a lot of stuff from<br>
reporters quoting seemingly credible medical authorities. However, what<br>
you mostly find is medical authorities endorsing following up an initial<br>
J&J regime with one of the two mRNA boosters, on grounds of the latter<br>
not coding for the for the exact same part of the spike protein.<br>
<br>
Whether informed sources would recommend J&J as a 2nd booster after<br>
three Pfizer shots is unclear. Complicating that calculation is the<br>
observed fact that the J&J vaccine has never generated as strong an<br>
immune response as the mRNA vaccines.<br>
<br>
If you trust your primary care physician's advice, asking him/her might<br>
be a reasonable thing to do.<br>
<br>
-- <br>
Cheers, "Public health is not private health. Epidemics are not personal<br>
Rick Moen diseases, and pandemics are not even national: They take place <br>
<a href="mailto:rick@linuxmafia.com" rel="noreferrer noreferrer noreferrer" target="_blank">rick@linuxmafia.com</a> across the shared immune system of human society."<br>
McQ! (4x80) -- Indi Samarajiva, <a href="https://t.co/bW2w059PYp" rel="noreferrer noreferrer noreferrer noreferrer" target="_blank">https://t.co/bW2w059PYp</a><br>
<br>
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