<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">Something I wrote for the Baypiggies list.</span></div><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><div class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br class=""></span></div>On Mon, Dec 13, 2021, at 3:26 PM, $SOMEONE wrote:</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><blockquote type="cite" style="font-family: LucidaGrande;" class="">It's time to stop playing pandemic.<br class=""></blockquote><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">Seriously. That's where you're going with this. *side eye*</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">* We have had 800,000 deaths from Covid in the US. That's still going on. It's not *just* a mass casualty event, it's also a mass disabling event.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">* We have a national shortage of doctors and nurses (and everything else in healthcare) because of the sheer horror of it all.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://morningconsult.com/2021/10/04/health-care-workers-series-part-2-workforce/" style="font-family: LucidaGrande;" class="">https://morningconsult.com/2021/10/04/health-care-workers-series-part-2-workforce/</a><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">Much of that shortage is caused by misbehavior on the part of patients and their families. Especially the families.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://www.reddit.com/r/QAnonCasualties/comments/rakxun/my_career_of_treating_patients_has_ended/" style="font-family: LucidaGrande;" class="">https://www.reddit.com/r/QAnonCasualties/comments/rakxun/my_career_of_treating_patients_has_ended/</a><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""> (Note: some very visceral descriptions from this doctor.)</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">* Even morticians have been getting PTSD.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://news.yahoo.com/texas-embalmer-shares-nightmare-covid-130817817.html" style="font-family: LucidaGrande;" class="">https://news.yahoo.com/texas-embalmer-shares-nightmare-covid-130817817.html</a><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">* Covid is the first endothelial pandemic we've had (so far as we know). The endothelium lines the blood vessels:</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://academic.oup.com/eurheartj/article/41/32/3038/5901158" style="font-family: LucidaGrande;" class="">https://academic.oup.com/eurheartj/article/41/32/3038/5901158</a><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">* The endothelium forms the blood/brain barrier:</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://en.wikipedia.org/wiki/Blood–brain_barrier" style="font-family: LucidaGrande;" class="">https://en.wikipedia.org/wiki/Blood–brain_barrier</a><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">That's why you can get things that cross the blood/brain barrier from Covid like autoimmune encephalitis. Fun times.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://www.medrxiv.org/content/10.1101/2020.07.23.20160770v1" style="font-family: LucidaGrande;" class="">https://www.medrxiv.org/content/10.1101/2020.07.23.20160770v1</a><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""> (preprint, full text) </span><a href="https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2020.20081236" style="font-family: LucidaGrande;" class="">https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2020.20081236</a><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""> (peer reviewed, excerpt)</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">* The endothelium also performs kidney (glomerular) filtration:</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://www.osmosis.org/learn/Glomerular_filtration" style="font-family: LucidaGrande;" class="">https://www.osmosis.org/learn/Glomerular_filtration</a><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">That's why there have been cases of new onset Diabetes type 1 and type 2 as a side effect of Covid, as well as kidney failure. (I can't find my papers on that at the moment, and I don't feel like digging for it.)</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">* The endothelium also controls things like hemostasis, whether you've got enough blood everywhere or not. Coagulation, or letting the mast cells know to release some of that sweet heparin for anti-coagulation, etc. Then you've got fibrin that's resistant to fibrinolysis and thus leads to the microclots that are known in many aspects of covid (e.g., "covid toes"), etc.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380922/" style="font-family: LucidaGrande;" class="">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380922/</a><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">And so on. Nothing like having a lifelong (possibly) endothelial disease, e.g., atherosclerosis.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><a href="https://en.wikipedia.org/wiki/Endothelial_dysfunction" style="font-family: LucidaGrande;" class="">https://en.wikipedia.org/wiki/Endothelial_dysfunction</a><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">So, dude, you do you, but I'd be happy to be at a conference of the vaccinated.</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">Deirdre</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">PS - reminder to anyone reading that vaccines and booster shots are available if you haven't gotten yours yet.</span><div class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><br class=""></span></div></body></html>