<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div><blockquote type="cite" class=""><div class="">On Sep 23, 2020, at 12:23, Rick Moen <<a href="mailto:rick@linuxmafia.com" class="">rick@linuxmafia.com</a>> wrote:</div><br class="Apple-interchange-newline"><div class=""><span style="caret-color: rgb(0, 0, 0); font-family: LucidaGrande; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">I should also mention, however, _another_ scandal that haunts vaccine</span><br style="caret-color: rgb(0, 0, 0); font-family: LucidaGrande; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""><span style="caret-color: rgb(0, 0, 0); font-family: LucidaGrande; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none; float: none; display: inline !important;" class="">development: The 2017 Dengvaxia incident in the Philippines.</span><br style="caret-color: rgb(0, 0, 0); font-family: LucidaGrande; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class=""></div></blockquote></div><div class=""><br class=""></div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class="">What happens in the ADE case of dengue is the immune response to a different strain actually helps the other strain *gain access to the cell*. So it becomes a superhighway in. So not helpful. That’s why they were so angry about how the vaccine was handled, because basically they made a bunch of kids susceptible to hemorrhagic forms later in life. Ugh, so not good. Dengue is one of THE most painful illnesses there is, fwiw, on the order of bone cancer painful, just thankfully more short lived for most people.</div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><br class=""></div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class="">Oh, and bonus: dengue and SARS-CoV-2 can cross-react on tests. :P 2020, WTAF. <a href="https://www.medrxiv.org/content/10.1101/2020.07.03.20145797v1" class="">https://www.medrxiv.org/content/10.1101/2020.07.03.20145797v1</a> (not the first or only paper on this, fwiw; the first was in The Lancet).</div><div style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);" class=""><br class=""></div><div class="">While it doesn’t get a lot of press (for very good reason), ADE is always a concern in vaccine development even apart from dengue being a special snowflake. (Some may recall my trying to explain the issues of ADE to Ruben in the past.)</div><div class=""><br class=""></div><div class="">If you over-excite the immune system, you WILL get a cytokine storm, as we’ve seen with COVID-19 (and one of the reasons there’s been ADE concern about SARS-CoV-2 vaccines). There were also cytokine storms with SARS and MERS fwiw, so it’s not like there haven’t been similar problems in the betacoronavirus family.</div><div class=""><br class=""></div><div class="">The other thing: we have *NO* workable long-term vaccine for any mammal in the coronavirus family. None. Zip. So it’s not like we can even borrow that expertise from veterinary.</div><div class=""><br class=""></div><div class="">So expecting something to magically arrive out of thin air when we’ve just not had a vaccine for all six other human viruses in the family all this time is ludicrous.</div><div class=""><br class=""></div><div class="">They all have serious issues, and the coronavirus family is just tricksy as hell.</div><div class=""><br class=""></div><div class="">So this “herd immunity” and “open up” rhetoric is bullshit designed to get people permanently maimed or killed.</div><div class=""><br class=""></div><div class=""></div><blockquote type="cite" class=""><div class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">The other thing I wanted to mention is that it's pretty much universally</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">acknowledged that the Feb. 2019 _measles_ outbreak in Metro Manila and </span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">nearby parts of the islands was fallout from the Dengvaxia scandal</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">causing such widespread paranoia among Filipino parents about vaccine</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">safety the the country had only 74% measles vaccine coverage at the time</span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">of the outbreak. (About 95% coverage is required to prevent outbreaks, </span><br style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class=""><span style="caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">on account of the measles vaccine's extremely high infectivity.)</span></div></blockquote><div class=""><br class=""></div>Oh, and the best part about measles outbreaks?<div class=""><br class=""></div><div class="">MEASLES ERASES THE IMMUNE SYSTEM’S MEMORY.</div><div class=""><br class=""></div><div class=""><a href="https://news.harvard.edu/gazette/story/2019/10/how-measles-wipes-out-the-bodys-immune-memory/" class="">https://news.harvard.edu/gazette/story/2019/10/how-measles-wipes-out-the-bodys-immune-memory/</a></div><div class=""><br class=""></div><div class="">So it’s not just skipping that one vaccine, it’s doing a pew-pew-pew (technical term) on any others they may have had, as well as any other acquired immunity.<br class=""><div class=""><br class=""></div><div class="">Deirdre</div></div></body></html>