<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class="">Okay, there’s *definitely* anomalies here.<div class=""><br class=""></div><div class="">In addition to the previously-mentioned study:</div><div class=""><br class=""></div><div class="">1. …tests aren’t picking it up.<br class=""><div class=""><br class=""></div><div class=""><span class="" style="font-family: LucidaGrande; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);">Brazil recently produced a report on the accuracy of their approved tests and it has a stunner of a line near the end:</span><br class="" style="font-family: LucidaGrande; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><br class="" style="font-family: LucidaGrande; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><a href="https://www.sciencedirect.com/science/article/pii/S1413867020300295" class="" style="font-family: LucidaGrande;">https://www.sciencedirect.com/science/article/pii/S1413867020300295</a><br class="" style="font-family: LucidaGrande; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><br class="" style="font-family: LucidaGrande; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><span class="" style="font-family: LucidaGrande; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);">"However, it is important to highlight that the rate of false negative results from tests which detect SARS-CoV-2 IgM antibodies, used for detection of COVID-19 in the acute phase, ranged from 10 to 44%.”</span></div><div class=""><span class="" style="font-family: LucidaGrande; caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0);"><br class=""></span></div><div class=""><span style="color: rgb(0, 0, 0); font-family: LucidaGrande;" class="">2. …because it’s not there.</span></div></div><div class=""><font color="#000000" face="LucidaGrande" class=""><br class=""></font></div><div class=""><a href="https://www.medrxiv.org/content/10.1101/2020.05.18.20105155v1" style="font-family: LucidaGrande;" class="">https://www.medrxiv.org/content/10.1101/2020.05.18.20105155v1</a></div><div class=""><font color="#000000" face="LucidaGrande" class=""><br class=""></font></div><div class=""><font color="#000000" face="LucidaGrande" class="">Big long study (preprint) of 1850 pts from China (preprint) says that:</font></div><div class=""><font color="#000000" face="LucidaGrande" class=""><br class=""></font></div><div class=""><font color="#000000" face="LucidaGrande" class="">While IgM was rarely detected (32.5%) during the early stage (SupplementaryFigure S1B). 97.4% of the confirmed patients have positive IgM or IgG at the first 1 week after symptom onset, indicating that the combination of IgM and IgG is necessary for auxiliary diagnosis. (p.8)</font></div><div class=""><font color="#000000" face="LucidaGrande" class=""><br class=""></font></div><div class=""><font color="#000000" face="LucidaGrande" class="">So it seems the body’s compensating by producing IgG instead (makes sense) and the COVID-19 severity is correlated to certain measurable relationships between certain antibody levels. Which makes some sense. More interesting was that those relationships predicted hospital *readmission*.</font></div><div class=""><font color="#000000" face="LucidaGrande" class=""><br class=""></font></div><div class=""><font color="#000000" face="LucidaGrande" class="">We still don’t know what’s happening to the IgM. My leading suspicion is protein folding (since a molecule that is made correctly can be made to fold incorrectly, rendering it useless), but I could easily be wrong on that.</font></div><div class=""><font color="#000000" face="LucidaGrande" class=""><br class=""></font></div><div class=""><font color="#000000" face="LucidaGrande" class="">Deirdre</font></div></body></html>