[conspire] COVID at the end of 2021

[Les Faby]

Monica Gandhi is an excellent source.
The J&J response improves dramatically with a second well-spaced dose.
Initially I had mistakenly assumed Adenovirus vaccines would not work well
for multiple doses because the immune system would be primed to destroy it.
Fortunately,  this has not been a problem.

On Sun, Jan 2, 2022, 12:09 AM Rick Moen <rick at linuxmafia.com> wrote:

> Quoting Les Faby (lfaby2018 at gmail.com):
>
> > J&J encodes the same full spike D614G variant with 2 proline
> > substitutions to encode the pre-fusion spike protein as the mRNA
> > vaccines.
> >
> > Reference: How the Johnson & Johnson Vaccine Works
> > https://nyti.ms/2WuvMsA
>
> Appreciated.  For whatever it's worth, I was relying on this statement
> in the press:
>
>   “There is something that makes sense about it,” says Monica Gandhi,
>   M.D., an infectious disease expert and professor of medicine at
>   University of California, San Francisco. And that’s because J&J’s viral
>   vector vaccine and the mRNA vaccines from Pfizer and Moderna “don't
>   actually code for the exact same part of the spike protein,” she
>   says.
>
>   Meaning that while the two different vaccine technologies work in a
>   similar way — they direct the body to make a harmless piece of the
>   coronavirus’s signature spike protein so that the immune system
>   can learn to recognize it as an invader and attack it if ever faced with
>   the real deal — the proteinsthat they instruct the cells to make vary.
>
>   “So you're going to get more of a response, that would be the hope, by
>   giving them both because you cover more of the spike protein. You have
>   different antigens [foreign substances that induce an immune response]
>   that you see,” Gandhi says.
>
>   Keep in mind, too, that the J&J vaccine has never generated as strong an
>   immune response as the mRNA vaccines, says Isaac Weisfuse, M.D., a
>   medical epidemiologist and an adjunct professor at Cornell University
>   Public Health. And “if you boost with something that historically has
>   more efficacy,” you’re going to see a higher antibody level.
>
>
> https://www.aarp.org/health/conditions-treatments/info-2021/mixing-matching-covid-vaccines.html
>
> As mentioned, this is outside of both my expertise and the medical
> subjects I've tried to study up on -- so, asked a question without
> opportunity to study up, I'm reduced to the same sort of quick targeted
> Web searching we-lot use to quickly assess things -- something I would
> not trust on such a subject that is both technical and suffused with
> speculation and bad information.  In other words, caveat lector.
>
> --
> Cheers,        "Public health is not private health.  Epidemics are not
> personal
> Rick Moen      diseases, and pandemics are not even national:  They take
> place
> rick at linuxmafia.com          across the shared immune system of human
> society."
> McQ! (4x80)                  -- Indi Samarajiva, https://t.co/bW2w059PYp
>
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