[conspire] (forw) [skeptic] Vaccines are a very good idea, except when they aren't (was: Jab)

[Rick Moen]

I forgot to add a couple of things:

> I should also mention, however, _another_ scandal that haunts vaccine
> development:  The 2017 Dengvaxia incident in the Philippines.
[...]
> The incident is so infamous in the Phillipines that, when I went to look
> up details, I found an online newspaper article that speaks of the risk
> that a COVID-19 vaccine might turn out to be another Dengvaxia, and the
> paper didn't bother to explain the reference:  They assumed their
> readership already knew.

That article is here:
https://www.philstar.com/business/2020/08/14/2035262/dengvaxia-scandal-haunts-philippines-covid-19-vaccine-rush

Excerpt:

  From 2 years to 6 months

  The science and technology department assured the public of a thorough
  study of Sputnik V, but the government’s timeline for third phase of
  trials does not invite confidence. Testing will be accelerated from the
  typical 2 to 3 years to just 6 months. To compare, Sanofi Pasteur Inc.,
  the French pharmaceutical firm that developed Dengvaxia, spent 25 months
  for their Phase III testing. 

Ding!

  “The question now shifts as to how long will you have to wait to
  conclude the Phase III of clinical trials. What you need to see is what
  happens down the line three, six months or even a year after. Will there
  be side effects?” Tamesis said. 

  To be fair, Co said a vaccine’s efficacy and safety provisions, even
  when already in market, is consistently reevaluated and updated. In the
  end, it is up to health officials to carefully evaluate whether the
  vaccine is safe for public usage with the information they have at hand.

  “There are many ways to accelerate it (Phase III). For example, if the
  manufacturer is sure of its product, it can start manufacturing already
  while they are still in clinical trials,” he said.

  “If Phase III isn’t successful, then it goes back to square one and many
  drugs had that happen to them,” he added.


Fortunately, our own Federal watchdogs are the gold standard, right? 
Right?  Um, _right_?  Hold that thought.

More to come about the Toddler Administration's systematic attacks on
the credibility and effectiveness of our public health agencies.
Particularly damaged by these criminals is the CDC, whose many decades
of world credibility have pretty much been destroyed for fundamentally
stupid reasons -- rather like the Federal Aviation Administration before
it.


The other thing I wanted to mention is that it's pretty much universally
acknowledged that the Feb. 2019 _measles_ outbreak in Metro Manila and 
nearby parts of the islands was fallout from the Dengvaxia scandal
causing such widespread paranoia among Filipino parents about vaccine
safety the the country had only 74% measles vaccine coverage at the time
of the outbreak.  (About 95% coverage is required to prevent outbreaks, 
on account of the measles vaccine's extremely high infectivity.)

In consequence, there were about 25,000 measles cases and 338 confirmed
deaths, almost all of which could have been avoided with vaccination.

  In addition to boiling anger over the incident 
> in the Phillipines, there is also the charge the Sanofi used Filipinos
> as 'guinea pigs', sacrificing their children because they were in a
> conveniently powerless tropical country.  Criminal charges have been
> filed against officials involved. 
> 
> 
> 'ADE' remains a significant risk for the current vaccine development, e.g.:
> 
>   Abstract
> 
>   Antibody-based drugs and vaccines against severe acute respiratory
>   syndrome coronavirus 2 (SARS-CoV-2) are being expedited through
>   preclinical and clinical development. Data from the study of SARS-CoV
>   and other respiratory viruses suggest that anti-SARS-CoV-2 antibodies
>   could exacerbate COVID-19 through antibody-dependent enhancement (ADE).
>   Previous respiratory syncytial virus and dengue virus vaccine studies
>   revealed human clinical safety risks related to ADE, resulting in failed
>   vaccine trials. Here, we describe key ADE mechanisms and discuss
>   mitigation strategies for SARS-CoV-2 vaccines and therapies in
>   development. We also outline recently published data to evaluate the
>   risks and opportunities for antibody-based protection against
>   SARS-CoV-2.
> 
> https://www.nature.com/articles/s41564-020-00789-5
> 
> 
> [1] This is often so similar in severity to the effect of paralytic
> polio that modern scientists suspect that FDR's symptoms that he
> suffered starting in 1922 were actually more consistent with
> Guillain–Barré syndrome autoimmune neuropathy than with polio.
> 
> 
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