[conspire] Long-term vs. short-term antibodies

[Ruben Safir]

On Thu, May 14, 2020 at 02:05:03AM -0700, Deirdre Saoirse Moen wrote:
> One of the peculiar things I’ve seen in two papers now, but no one discussing (and I’ve never seen it in other virus outbreaks I was watching closely), is this:
> 

This is one of those kind of studies that you just shrug your shoulder
and say, eh, I don't believe it.

I am not aware of a mechanism form B-Cell mediation without Somatic
Hypermutation

Anything is possible but one study can't be held in such regard for
clinical purposes, especially if not supported by a mountain of
contrary scientific study.

https://www.sciencedirect.com/science/article/pii/B9780123979339000205
https://www.sciencedirect.com/science/article/pii/B0122267656002139?via%3Dihub
https://www.sciencedirect.com/science/article/pii/B9780123852458000054

Those BCells are putating somehow

> Classically, the body makes IgM antibodies while fighting the infection. Then, when it’s on the mend, it makes IgM and IgG, and eventually makes only IgG. This is one way you can tell a (systemic) infection has cleared the body: the IgM is gone.
> 
> With that in mind, in this study, 10 out of 26 COVID-19 patients created IgG antibodies *before* IgM, backwards of the usual.
> 
> https://www.nature.com/articles/s41591-020-0897-1/figures/2
> 
> So the gotcha here is that you could easily miss an active infection by looking for one and not the other, or by interpreting it in the classical way. I’ll be looking for other similar studies, but this one was definitely unexpected.
> 
> I’d be even more interested as to why.
> 
> Deirdre

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