[conspire] conspire Digest, Vol 202, Issue 26
Rashmi Nunn
r.nunn at stanfordalumni.org
Sun Aug 30 12:27:08 PDT 2020
Glad to hear that you are better since January! Found only 3 articles with
the keywords below.
Dysautonomia and PRES (Posterior Reversible Encephalopathy
(leukoencephalopathy) syndrome) refs.
—
3 articles re: covid-19 and PRES
https://pubmed.ncbi.nlm.nih.gov/
<https://pubmed.ncbi.nlm.nih.gov/?term=%28+Posterior+leukoencephalopathy+syndrome+and+covid+Posterior+leukoencephalopathy+syndrome.&ac=yes&cauthor_id=None&user_filter=&schema=none&page=1&whatsnew=None&show_snippets=on&format=abstract&sort=relevance&sort_order=desc&size=10>
PMID
32474362
32439646
32574838
—
Kishfy L, Casasola M, Banankhah P, et al. Posterior reversible
encephalopathy syndrome (PRES) as a neurological association in severe
Covid-19. *J Neurol Sci*. 2020;414:116943. doi:10.1016/j.jns.2020.116943
- Division of Neurology, Mount Auburn Hospital, Harvard Medical School,
Cambridge, MA, USA. Electronic address: mabdelrazek at mah.harvard.edu.
- PMID: 32474362
- PMCID: PMC7245308
<http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7245308/>
Abstract
•PRES is potentially a complication of severe SARS-CoV-2 infection.•Consider
PRES in COVID-19 patients with altered mentation.•Consider tight blood
pressure control in ventilated patients with COVID-19.•Hypertensive
encephalopathy may prolong ventilator times in COVID-19 patients.
*Keywords: *Hypertensive encephalopathy; PRES; Posterior reversible
encephalopathy syndrome; Reversible posterior leukoencephalopathy syndrome;
SARS-CoV-2; coronavirus disease 2019.
On Sun, Aug 30, 2020 at 01:00 <conspire-request at linuxmafia.com> wrote:
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> Today's Topics:
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>
>
> 1. COVID-19 and Dysautonomia (Deirdre Saoirse Moen)
>
>
>
>
>
> ----------------------------------------------------------------------
>
>
>
> Message: 1
>
> Date: Sat, 29 Aug 2020 11:49:38 -0700
>
> From: Deirdre Saoirse Moen <deirdre at deirdre.net>
>
> To: Conspire List <conspire at linuxmafia.com>
>
> Subject: [conspire] COVID-19 and Dysautonomia
>
> Message-ID: <75E48917-A197-4A80-BC0C-3B39AEEED5CB at deirdre.net>
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> Content-Type: text/plain; charset=utf-8
>
>
>
> I?m sure many of you have heard about some of the stories about ?long
> haulers? - people who?ve had lingering covid symptoms for months on end,
> and a seemingly random collection of them. One such story:
>
>
>
>
> https://theconversation.com/im-a-covid-19-long-hauler-and-an-epidemiologist-heres-how-it-feels-when-symptoms-last-for-months-143676
>
>
>
> * racing heart
>
> * heat intolerance
>
> * gastrointestinal issues
>
> * ringing in the ears
>
> * chest pains
>
>
>
> Sounds pretty random, right?
>
>
>
> But it?s not.
>
>
>
> Even physicians have reported being blown off by colleagues, though, when
> reporting symptoms like these, being told they?re all in their head. Which
> is funny because it both is and isn?t true. These are autonomic nervous
> system related things, and dysautonomia is common in autoimmune diseases,
> post-viral complications, and a lot of long-term failure diseases/syndromes
> like Parkinson's.
>
>
>
> https://en.wikipedia.org/wiki/Dysautonomia
>
>
>
> So it could be in the hypothalamus (in one?s head), or at any point
> between there and whatever vertebra controls that particular function (not
> in one?s head), or enroute to final delivery (cardiac muscle). I also find
> it cool that the sympathetic and parasympathetic are sort of opposite land.
> One YouTube doctor who has given some interesting talks about dysautonomia
> describes the two systems as a teeter-totter.
>
>
>
> Ever since I got covid in January, I?ve had a nagging occasionally
> annoyingly high racing heartbeat. One day, it was concerningly high (not
> super high, just sustained), and I greyed out, so Rick took me to the ER. I
> went through the usual diagnostic tree, wore a heart monitor for two weeks.
>
>
>
> Nothing.
>
>
>
> It?s a good thing I was paying closer attention, huh?
>
>
>
> I should thank an asshole on reddit who said there was no evidence that
> covid affects the brain, because I then went and found a bunch of
> covid/brain papers including this rather horrifying autoimmune encephalitis
> one:
>
>
>
> https://www.medrxiv.org/content/10.1101/2020.07.23.20160770v1
>
>
>
> The body of the text mentions ?autonomic instability,? and searching on
> that on wikipedia brought me to https://en.wikipedia.org/wiki/Dysautonomia
> (which is what I expected, I was just checking).
>
>
>
> Anyhow, I started paying close attention to *when* my heart rate was
> unusually high: when I was standing, and it went up over 130 when I was
> standing in front of the microwave a couple extra minutes waiting for
> coffee.
>
>
>
> In humans, 70% of our blood volume is below our heart when we?re standing,
> but for quadripeds, 70% of blood volume is at or above heart level when
> they?re standing. So we do have an elevation of heart rate normally to
> compensate for that. It?s just that the signaling is off in some people.
> Which seems to be what?s happening:
>
>
>
> https://en.wikipedia.org/wiki/Postural_orthostatic_tachycardia_syndrome
>
>
>
> Fancy way of saying my heart rate goes up too much when I stand, as the
> heart tries to compensate for the lack of blood flow to the brain.
> Functionally, I have altitude sickness when I stand up.
>
>
>
> I?d already come to a lot of the same conclusions: my best exercises
> throughout life were bicycling, rowing, and swimming or yoga or strength
> training, preferably with intermittent horizontal parts.
>
>
>
> I just had no idea that my headaches, migraines, difficulty concentrating,
> frequent nausea, chronic pain, altitude intolerance, and heat/cold
> intolerance were directly related to that.
>
>
>
> Anyhow, I half think it?s funny that no one was able to figure it out for
> decades despite my filing of bug reports :P but then I was able to figure
> it out myself while *in the middle of the systemic effects of it*. Ugh.
> Finally found that repro case.
>
>
>
> So, for me, long covid mostly seems to have been a dialing to 11 something
> that was already bad, just not something that sent me to the ER bad, and
> something that had been missed for a long time. How long? I suspect I?d had
> it since middle school, but it was probably only obvious to others in
> things like altitude intolerance back then.
>
>
>
> Deirdre
>
>
>
>
>
>
>
>
>
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> End of conspire Digest, Vol 202, Issue 26
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> *****************************************
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